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Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress

The findings were published today in Acta Neuropathologica Communications

Edwards S, Evans P, Hucklebridge F, Clow A (2001)

In a scopolamine-induced cognitive impairment model in rats, Dihexa administered intracerebroventricularly (0.1 to 1.0 nmol), intraperitoneally (up to 0.5 mg/kg/day), or orally (up to 2.0 mg/kg/day) significantly improved performance on the Morris water maze (reduced latency to locate the hidden platform and increased time spent in the target quadrant during probe trials) compared with scopolamine-treated, Dihexa-untreated animals, with the highest doses producing performance indistinguishable from non-impaired controls

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